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Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the continualreassessment method

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《医学前沿（英文）》 2012年第6卷第3期页码 288-295 doi: 10.1007/s11684-012-0208-4

摘要：

Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants were allocated a different tramadol dose. Pain intensity was measured by face, legs, activity, cry, consolability (FLACC) measurement at 3-hour intervals. Tramadol was considered ineffective if the FLACC score was higher than 4 in 10 at anytime. In phase 1, seven dose levels were used within the range 0.1–0.4 mg?kg^-1·h^-1. Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?kg^-1·h^-1 in phase 2. Phase 2 was insufficient to identify the MED. In phase 3, local anesthetic wound infiltration was introduced, and the tramadol dose levels tested were the same as in phase 1. The successful analgesia probability of tramadol 0.4 mg?kg^-1?h^-1 was 82.1% (95% CI, 0.742–0.925) in phase 1. In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg^-1?h^-1. Phase 1 and phase 2 were insufficient to identify the MED. In phase 3, the successful analgesia probability for dose 0.35 mg?kg^-1?h^-1was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia for surgeries considered to cause moderate-to-severe postoperative pain in infants if used as the sole analgesic, and that local anesthetic wound infiltration enhances the efficacy of tramadol.

关键词： tramadol minimum effective dose postoperative analgesia infants continual reassessment method

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重组生物技术制品生产工艺变更的病毒安全性风险再评估策略

赛文博, 贾东晨, 陈昊, 韦薇

《工程（英文）》 2024年第32卷第1期页码 15-18 doi: 10.1016/j.eng.2023.10.003

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Reassessment of fenestration characteristics for residential buildings in hot climates: energy and economic

Ali ALAJMI, Hosny ABOU-ZIYAN, Hamad H. Al-MUTAIRI

《能源前沿（英文）》 2022年第16卷第4期页码 629-650 doi: 10.1007/s11708-021-0799-z

摘要： This paper attempts to resolve the reported contradiction in the literature about the characteristics of high-performance/cost-effective fenestration of residential buildings, particularly in hot climates. The considered issues are the window glazing property (ten commercial glazing types), facade orientation (four main orientations), window-to-wall ratio (WWR) (0.2–0.8), and solar shading overhangs and side-fins (nine shading conditions). The results of the simulated runs reveal that the glazing quality has a superior effect over the other fenestration parameters and controls their effect on the energy consumption of residential buildings. Thus, using low-performance windows on buildings yields larger effects of WWR, facade orientation, and solar shading than high-performance windows. As the WWR increases from 0.2 to 0.8, the building energy consumption using the low-performance window increases 6.46 times than that using the high-performance window. The best facade orientation is changed from north to south according to the glazing properties. In addition, the solar shading need is correlated as a function of a window-glazing property and WWR. The cost analysis shows that the high-performance windows without solar shading are cost-effective as they have the largest net present cost compared to low-performance windows with or without solar shading. Accordingly, replacing low-performance windows with high-performance ones, in an existing residential building, saves about 12.7 MWh of electricity and 11.05 tons of CO₂ annually.

关键词： parametric analysis high-performance window window-to-wall ratio (WWR) facade orientation solar shading cost analysis

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液压冲击机构工作参数调节机理与控制策略S

刘忠,,褚福磊,龙国键,廖永忠

《中国工程科学》 2005年第7卷第10期页码 73-77

摘要：

针对目前国内外液压冲击机械工作参数调节方法的局限性，提出了行程无级调节原理，设计了一种新型的行程无级调节装置，并对该装置进行了数字仿真研究；在此基础上设计了一种基于微机控制的无级调节工作参数的液压冲击机构，论述了其设计原理、结构特点、技术性能和控制策略。

关键词：液压冲击机构无级调节工作参数控制系统

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Comparison of shallow tunneling method with pile and rib method for construction of subway station in

Sina AMIRI; Ali Naghi DEHGHAN

《结构与土木工程前沿（英文）》 2022年第16卷第6期页码 704-717 doi: 10.1007/s11709-021-0746-4

摘要： In the present study, a comparison between the new shallow tunneling method (STM) and the traditional pile and rib method (PRM) was conducted to excavate and construct subway stations in the geological conditions of Tehran. First, by selecting Station Z6 located in the Tehran Subway Line 6 as a case study, the construction process was analyzed by PRM. The maximum ground settlement of 29.84 mm obtained from this method was related to the station axis, and it was within the allowable settlement limit of 30 mm. The acceptable agreement between the results of numerical modeling and instrumentation data indicated the confirmation and accuracy of the excavation and construction process of Station Z6 by PRM. In the next stage, based on the numerical model validated by instrumentation data, the value of the ground surface settlement was investigated during the station excavation and construction by STM. The results obtained from STM showed a significant reduction in the ground surface settlement compared to PRM. The maximum settlement obtained from STM was 6.09 mm as related to the front of the excavation face. Also, the sensitivity analysis results denoted that in addition to controlling the surface settlement by STM, it is possible to optimize some critical geometric parameters of the support system during the station excavation and construction.

关键词： shallow tunneling method pile and rib method ground surface settlement subway station construction numerical modeling

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

《结构与土木工程前沿（英文）》 2014年第8卷第4期页码 448-455 doi: 10.1007/s11709-014-0262-x

摘要： Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

关键词： JH classification Q and RMR classification new method

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Independent cover meshless particle method for complex geotechnical engineering

Jianqiu WU, Yongchang CAI

《结构与土木工程前沿（英文）》 2018年第12卷第4期页码 515-526 doi: 10.1007/s11709-017-0428-4

摘要： A new Independent Cover Meshless Particle (ICMP) method is proposed for the analysis of complex geotechnical engineering. In the ICMP method, the independent rectangular cover regardless of the shape of the analysis model is employed as the influence domain of each discrete node, the general polynomial is employed as the meshless interpolation function of the independent nodal cover, and the Cartesian Transformation Method (CTM) is used for the numerical integration of the nodal covers cut by material interfaces, joints, cracks and faults. The present method has a simple formulation and a low computational cost, and is easy for the numerical analysis and modeling of complex geotechnical engineering. Several typical numerical examples are presented to demonstrate the accuracy and robustness of the proposed method.

关键词： meshless method particle method independent cover CTM geotechnical engineering

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3D mode discrete element method with the elastoplastic model

Wei HU, Feng JIN, Chong ZHANG, Jinting WANG

《结构与土木工程前沿（英文）》 2012年第6卷第1期页码 57-68 doi: 10.1007/s11709-012-0139-9

摘要： The three-dimensional mode-deformable discrete element method (3MDEM) is an extended distinct element approach under the assumptions of small strain, finite displacement, and finite rotation of blocks. The deformation of blocks is expressed by the combination of the deformation modes in 3MDEM. In this paper, the elastoplastic constitutive relationship of blocks is implemented on the 3MDEM platform to simulate the integrated process from elasticity to plasticity and finally to fracture. To overcome the shortcomings of the conventional criterion for contact fracturing, a new criterion based on plastic strain is introduced. This approach is verified by two numerical examples. Finally, a cantilever beam is simulated as a comprehensive case study, which went through elastic, elastoplastic, and discontinuous fracture stages.

关键词： mode discrete element method elastoplastic numerical method discontinuum contact

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The smoothed finite element method (S-FEM): A framework for the design of numerical models for desired

Gui-Rong Liu

《结构与土木工程前沿（英文）》 2019年第13卷第2期页码 456-477 doi: 10.1007/s11709-019-0519-5

摘要：

The smoothed finite element method (S-FEM) was originated by G R Liu by combining some meshfree techniques with the well-established standard finite element method (FEM). It has a family of models carefully designed with innovative types of smoothing domains. These models are found having a number of important and theoretically profound properties. This article first provides a concise and easy-to-follow presentation of key formulations used in the S-FEM. A number of important properties and unique features of S-FEM models are discussed in detail, including 1) theoretically proven softening effects; 2) upper-bound solutions; 3) accurate solutions and higher convergence rates; 4) insensitivity to mesh distortion; 5) Jacobian-free; 6) volumetric-locking-free; and most importantly 7) working well with triangular and tetrahedral meshes that can be automatically generated. The S-FEM is thus ideal for automation in computations and adaptive analyses, and hence has profound impact on AI-assisted modeling and simulation. Most importantly, one can now purposely design an S-FEM model to obtain solutions with special properties as wish, meaning that S-FEM offers a framework for design numerical models with desired properties. This novel concept of numerical model on-demand may drastically change the landscape of modeling and simulation. Future directions of research are also provided.

关键词： computational method finite element method smoothed finite element method strain smoothing technique smoothing domain weakened weak form solid mechanics softening effect upper bound solution

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Explicit optimization method for cutting-screw-thread on the basis of dual-RSM

Zhengbao LEI, Shubin WEI, Qingyun DU

《机械工程前沿（英文）》 2010年第5卷第4期页码 423-430 doi: 10.1007/s11465-010-0109-7

摘要： To obtain the explicit function for optimizing the cutting-screw-thread (CST) in crash, the simulations of frontal crash at the speed of 56 km/h have been carried out in VPG. The peak acceleration in crash has been taken as the evaluation index of energy absorption characteristics. First, the single factor experiment was taken based on six parameters affecting on the absorption characteristics of CST. Second, the peak acceleration function of each parameter by using response surface method (RSM) is obtained. Third, the explicit resultant peak acceleration function of six parameters by using RSM again is obtained. A dual RSM-based explicit method is proposed. According to this function, the best size dimensions of CST in different crash conditions could be easily obtained. Finally, an example shows that the values of the calculation errors for simulation value and target value (40 g) are 3.6% and 1.3%, respectively. This method can satisfy the demand for engineering accuracy.

关键词： vehicle engineering crash safety explicit method response surface method

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Application of random set method in a deep excavation: based on a case study in Tehran cemented alluvium

Arash SEKHAVATIAN, Asskar Janalizadeh CHOOBBASTI

《结构与土木工程前沿（英文）》 2019年第13卷第1期页码 66-80 doi: 10.1007/s11709-018-0461-y

摘要： The design of high-rise buildings often necessitates ground excavation, where buildings are in close proximity to the construction, thus there is a potential for damage to these structures. This paper studies an efficient user-friendly framework for dealing with uncertainties in a deep excavation in layers of cemented coarse grained soil located in Tehran, Iran by non-deterministic Random Set (RS) method. In order to enhance the acceptability of the method among engineers, a pertinent code was written in FISH language of FLAC2D software which enables the designers to run all simulations simultaneously, without cumbersome procedure of changing input variables in every individual analysis. This could drastically decrease the computational effort and cost imposed to the project, which is of great importance especially to the owners. The results are presented in terms of probability of occurrence and most likely values of the horizontal displacement at top of the wall at every stage of construction. Moreover, a methodology for assessing the credibility of the uncertainty model is presented using a quality indicator. It was concluded that performing RS analysis before the beginning of every stage could cause great economical savings, while improving the safety of the project.

关键词： uncertainty reliability analysis deep excavations random set method finite difference method

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A simple method for evaluating liquefaction potential from shear wave velocity

Lianyang ZHANG,

《结构与土木工程前沿（英文）》 2010年第4卷第2期页码 178-195 doi: 10.1007/s11709-010-0023-4

摘要： The simplified procedure using shear wave velocity measurements is increasingly used to evaluate the seismic liquefaction potential of soils. This procedure is based on finding the boundary separating the liquefaction and non-liquefaction cases through the analysis of liquefaction case histories, following the general format of the Seed-Idriss simplified procedure based on standard penetration test (SPT) data. It is noted that many assumptions have been made in the simplified procedure. This paper develops a simple method for evaluating the liquefaction potential of soils from shear wave velocity by using the optimum seeking method to directly analyze the liquefaction history data and quantify the influence of major factors affecting the liquefactions potential of soils. The factors considered are the earthquake magnitude, the vertical effective overburden stress, the shear wave velocity, the peak acceleration at the ground surface of the site, and the fines content of the soil. The most important factor has been identified as the shear wave velocity. The developed method uses the measured data directly and in a very simple way. Neither stress-correction of shear wave velocity nor calculation of cyclic shear stress as in the simplified procedure is required. Comparisons indicate that the developed simple method has a higher success rate for evaluating liquefaction potential of soils than the simplified procedure. A case study is presented to illustrate the application of the developed simple method and further confirms its accuracy.

关键词： liquefaction earthquake simple method shear wave velocity case history introduction

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Thermo-elastic extended meshfree method for fracture without crack tip enrichment

A. ASADPOUR

《结构与土木工程前沿（英文）》 2015年第9卷第4期页码 441-447 doi: 10.1007/s11709-015-0319-5

摘要： This is the first manuscript presenting an extended meshfree method for thermo- elastic fracture which does not exploit a crack tip enrichment. The crack is modeled by partition of unity enrichment of the displacement and temperature field. Only a step function is employed that facilitates the implementation. To ensure that crack tip is at the correct position, a Lagrange multiplier field ahead of the crack tip is introduced along a line. The Lagrange multiplier nodal parameters are discretised with the available meshfree functions. Two benchmark examples illustrate the efficiency of the method.

关键词： meshfree method thermo-elasticity

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Level set band method: A combination of density-based and level set methods for the topology optimization

Peng WEI, Wenwen WANG, Yang YANG, Michael Yu WANG

《机械工程前沿（英文）》 2020年第15卷第3期页码 390-405 doi: 10.1007/s11465-020-0588-0

摘要： The level set method (LSM), which is transplanted from the computer graphics field, has been successfully introduced into the structural topology optimization field for about two decades, but it still has not been widely applied to practical engineering problems as density-based methods do. One of the reasons is that it acts as a boundary evolution algorithm, which is not as flexible as density-based methods at controlling topology changes. In this study, a level set band method is proposed to overcome this drawback in handling topology changes in the level set framework. This scheme is proposed to improve the continuity of objective and constraint functions by incorporating one parameter, namely, level set band, to seamlessly combine LSM and density-based method to utilize their advantages. The proposed method demonstrates a flexible topology change by applying a certain size of the level set band and can converge to a clear boundary representation methodology. The method is easy to implement for improving existing LSMs and does not require the introduction of penalization or filtering factors that are prone to numerical issues. Several 2D and 3D numerical examples of compliance minimization problems are studied to illustrate the effects of the proposed method.

关键词： level set method topology optimization density-based method level set band

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A new method for boring of non-circular holes

ZHANG Kai, HU De-jin

《机械工程前沿（英文）》 2006年第1卷第4期页码 456-460 doi: 10.1007/s11465-006-0058-3

摘要： A revolving electromagnetic actuation mechanism composed of an electromagnetic stator and an electromagnetic rotor has been developed for boring non-circular holes. The main component of the rotor is a flexure-hinged based flexible body. There are four pole-pair coils in the stator supplying actuation currents. The micro-displacement between the stator and rotor can be controlled by changing the currents applied in the pole-pair coils. Through linearization of the actuation force near the static action point, a linear relationship between the control current and the actuation force was established, and the synchronizing control method of the electromagnetic actuation mechanism is presented here. With two-factor analysis of the linearization error of the actuation force, the influences of control current and micro-displacement to the linearization error of the actuation force were studied. Then, the principle for designing the basic parameters of the magnetic actuation mechanism is put forward. The calibration of the mechanism indicates that the relationship between the micro-displacement of the rotor and the control current has linear characteristics in the required micro-displacement range. Simulation tests show that the turning radius of the rotor changes with the control current. The proposed mechanism can feasibly supply a controllable micro displacement to the boring bar.

关键词： electromagnetic actuation control method displacement flexible body revolving electromagnetic